Research revealed that about 30% of families affected by heritable thoracic aortic diseases (HTAD), without a confirmed diagnosis of MFS or a similar syndrome, carry a responsible, disease-causing genetic mutation within the recognized HTAD-related genes (for example, Actin Alpha 2 (ACTA2), myosin heavy chain 11 (MYH11), myosin light chain kinase (MYLK), notch receptor 1 (NOTCH1) and similar, as reported by Milewicz et al.)[7,8]. Here, NOTCH1 is linked to Marfan syndrome.