In these models, similar to what is observed in AMD, suppression of TH activity via inhibition of DIO2, overexpression of DIO3, or deletion of TH receptors reduces photoreceptor degeneration [153,154], suggesting that intraretinal repression of TH signaling could be a protective strategy against both AMD and inherited retinal dystrophy. This evidence concerns the gene TH and age-related macular degeneration.