Furthermore, citrullination of MBP makes it vulnerable to post translational modifications by cathepsin D and matrix metalloproteinase-3 (MMP-3), resulting in alteration of the microstructure and affinity to the MHCII socket (or certain HLA-DRB components) and presumably playing a role in early neurodegeneration in MS [34]. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.