IFNG and myeloid sarcoma: Moreover, microglia provide a significant HLA-DR signature in the CNS with HLA-DR production, correlating with the level of active neuroinflammation and consequently being elevated in acute lesions and active demyelination sites; in close association with this, microglia have been shown to elevate HLA-DR expression in reaction to paracrine IFN-γ stimulation and other neuroinflammatory conditions in MS [61].