Furthermore, IL-17A has been observed to break down BBB in RRMS patients; and (2) IL-17 expression in astroglia is increased in EAE and excessive IL-17R ligation results in secretion of pro-inflammatory cytokines and destabilization of the BBB through astrogliosis [99,100]. The gene discussed is IL17A; the disease is relapsing-remitting multiple sclerosis.