TACR1 and attention deficit-hyperactivity disorder: Interestingly, unlike angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), including losartan, were not only unable to prevent hyperlocomotion and impulsive-like behavior, but also exacerbated locomotor activity in “knockout” mice (NK1R-/-) with behavior resembling ADHD [36].