CASP3 and lung carcinoma: Therefore, to extend the knowledge of the potential mechanisms of action of ciminalum–thiazolidinone hybrid molecules Les-45 and Les-247, we evaluated their cytotoxicity, effect on metabolic activity, caspase-3 activity, impact on the expression of genes and proteins involved in the inflammatory response, antioxidant defenses, and cytoskeleton rearrangement processes in healthy human fibroblasts (BJ) and the human lung carcinoma cell line (A549).