In subgroups based on neuropathy, there were no significant differences in MMP-3 median (IQR) plasma concentrations between the T1D group without neuropathy, which was 17.0 (8.2) ng/mL; T1D with neuropathy, which was 19.3 (15.6) ng/mL; and the control group, which was 13.2(13.8) ng/mL. This evidence concerns the gene MMP3 and neuropathy.