Similarly, Jia et al.’s [62] study on the H2B gene family, particularly H2BC21, showed its high expression correlates with poor glioma prognosis and is involved in critical cancer pathways like cell cycle regulation and immune responses, using data from TCGA, CGGA, and GEO, indicating its potential as a biomarker for glioma progression. This evidence concerns the gene H2BC21 and central nervous system cancer.