In particular, NLRP1 and NLRP3 inflammasomes and caspase-dependent pyroptosis in fibroblast-like synovial cells trigger the release of the high-mobility group box 1 (HMGB1) protein, which supports cartilage degradation and fuels the release of the proinflammatory cytokines that aggravate osteoarthritis [110]. This evidence concerns the gene HMGB1 and osteoarthritis.