Keeping in mind the relationship between PAS and the formation of senile plaques [28] and the presence in the Rhamnaceae family of plants with metabolites showing the ability inhibit AChE by interaction with PAS, we considered it interesting to study the effect of the chemical modification of ceanothic acid on the inhibitory activity of this compound on AChE and its interaction with PAS because molecules that act in this way offer a good potential for better treatment of AD. This evidence concerns the gene ACHE and Senile plaques.