CCND1 and mantle cell lymphoma: However, overexpressed CCND1 is not always pathognomonic for MCL initiation, development, and progression (CCND2, CCND3, CCNE translocations may alternatively deregulate cell cycle progression) [4], and comprehensive profiling at the genome, epigenome, transcriptome, and proteome level is often necessitated, although still far from clinical practice [3,6,7].