The potential role of SMAD2/3:SMAD4 and RUNX1 transcriptional regulation and the SUMOylation of transcription cofactors and DNA-related proteins during the first phase of MCL progression (Supplementary Table S5D) is pointed out by two distinct levels of analysis: the pathway enrichment analysis and the co-expression functional module alignment. The gene discussed is SMAD4; the disease is mantle cell lymphoma.