A total of 16 out of 24 pathways were disease-specific biological networks (e.g., “breast cancer” or “melanoma” pathways, Supplementary Table S5A); the remaining eight deregulated pathways were “p53” and “Wnt” signaling pathways, “cell cycle”, “cellular senescence”, “Hedgehog”/“prolactin”/“thyroid hormone”/“Hippo” signaling pathways (Figure 2B, Supplementary Table S5A). This evidence concerns the gene PRL and breast carcinoma.