M2b macrophages express TNF, IL-1β, IL-6, IL-10, iNOS, and low levels of IL-12 [196], which is involved in the regulation of immune responses, including the modulation of cell maturation, tissue stabilization, angiogenesis, extracellular matrix (ECM) synthesis, and tumor progression, as well as the recruitment of eosinophils and Th2 cells [11,154,197,198]. This evidence concerns the gene TNF and neoplasm.