IL1B and neoplasm: M2b macrophages express TNF, IL-1β, IL-6, IL-10, iNOS, and low levels of IL-12 [196], which is involved in the regulation of immune responses, including the modulation of cell maturation, tissue stabilization, angiogenesis, extracellular matrix (ECM) synthesis, and tumor progression, as well as the recruitment of eosinophils and Th2 cells [11,154,197,198].