Results showed that IL4R-Exo(si/mi) successfully decreased the levels of M2 markers and cytokines, including Arg-1, TFG-β, IL-10, and IL-4 and increased the expression of M1 cytokines, including IL-12 and IFN-γ in the lymphomononculear population of tumor tissues [253]. Here, IFNG is linked to neoplasm.