Gunassekaran et al. harnessed M1 macrophage-derived exosomes transfected with NF-KB p50 siRNA and miR-511-3p and surface-modified with IL-4RPep-1, an IL-4R-binding peptide, named IL4R-Exo(si/mi), to foster M1 polarization and target IL4R for the inhibition of tumor growth by reprogramming TAMs into M1-like macrophages in mice inoculated with breast or lung tumor cells. The gene discussed is NFKB1; the disease is neoplasm.