Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reversed diet-induced hepatic steatosis and insulin resistance, suggesting that PNPLA3-mediated lipid accumulation is possibly associated with DGAT2 signaling. The gene discussed is DGAT2; the disease is Hepatic steatosis.