Their hits elucidated the cyclin D3-cyclin-dependent kinase 2–4 (CDK2-4)/CCAAT-enhancer-binding proteins (C/EBP)/diacylglycerol acyltransferase 2 (DGAT2) pathway as contributing to endoplasmic reticulum stress-induced steatosis. The gene discussed is CCND3; the disease is steatosis.