Hunter et al. [107] observed a significant reduction in mRNA levels of glutathione S-transferase isoforms mu1 (GSTM1) and mu5 (GSTM5) in AMD patients compared to age-matched controls, particularly in the retinal pigment epithelium (RPE)/choroid and neurosensory retina. This evidence concerns the gene GSTM1 and age-related macular degeneration.