Cytotoxic CD4+ T cells express markers which have been implicated in atherosclerosis in PLWH, including CD57 (a marker of senescence), CX3CR1 (a chemokine receptor that homes cells to inflamed endothelium), and GPR56 (an adhesion g-coupled protein receptor that is expressed on exhausted T cells) [98,203,204,205]. This evidence concerns the gene CD4 and atherosclerosis.