AKT1 and neoplasm: In another study, Yi et al. [57] reported that synthetic peptides based on Yin Yang 1 protein binding (YPB) and oncoprotein binding (OPB) domain efficiently decrease proliferation and stimulate apoptosis of breast cancer cells, and inhibit tumor growth in vivo, mainly by enhancing the expression of PTENP1 and PTEN and reducing AKT activation.