In vitro results revealed that coupling of CTX onto the liposomal surface improves particle internalization into glioma cells compared to noncancer cells; nanoparticle-mediated miR-21 silencing increases PTEN and PDCD4 (tumor suppressors), activates caspase 3/7 and reduces the cell proliferation in glioblastoma and glioma cells. Here, PDCD4 is linked to central nervous system cancer.