ANA is composed of anti-nucleosomes, anti-dsDNA, anti-histones, anti-Sm, anti-RNP, anti-RO antibodies, and anti-La antibodies, among which anti-Sm antibodies and anti-dsDNA antibodies are SLE-specific antibodies, and the other antibodies are also found in other autoimmune diseases [22]. This evidence concerns the gene CALR and autoimmune disease.