CXCL12 and osteosarcoma: For instance, trimethylation at H3K27 represses the production of CXCL9 and CXCL10 in ovarian cancer, establishing an immune-suppressive TME [89], while DNMT1 is responsible for the decreased CXCL12 in osteosarcomas, resulting in reduced CTL recruitment at the cancer site [90].