Alzheimer’s disease (AD) is the most prevalent form of dementia, whose hallmark features are amnestic impairment, hippocampal atrophy, and the presence of extracellular, amyloid beta-containing (Aβ) senile plaques and hyperphosphorylated tau protein-containing intracellular neurofibrillary tangles in the nervous system [36]. Here, MAPT is linked to Alzheimer disease.