OXR1 and Parkinson disease: The level of OXR1 was found to be downregulated in a chemically induced (via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration) mouse model of PD, and over-expressing it alleviated behavioral symptoms, neuronal apoptosis, and neuronal loss in the substantia nigra pars compacta of PD mice and reduced oxidative damage in an MPP+-induced primary neuronal cell culture PD model [53].