In the case of air pollution (which contains FA), exposure to fine particulate matter 2.5 (PM2.5) is proposed to promote organ DNA damage, induce inflammation and oxidative stress in the brain, affect the deposition of β-amyloid, promote tau phosphorylation, and serve as a risk factor for AD, especially in subjects with APOE ε4 alleles [122,123,124]. The gene discussed is MAPT; the disease is Alzheimer disease.