DNA damage and DNA repair have been shown to be influenced by pathological forms of proteins (TDP-43, FUS, C9Orf72, α-synuclein, and tau) that accumulate in a number of age-related neurodegenerative diseases, including ALS [134], PD [58,135], and AD [136,137] as well as certain neuropsychiatric disorders [138]. Here, MAPT is linked to Alzheimer disease.