ATXN3 and Decreased liver function: When administered intravenously at high doses, AAV-PHP.B encoding ATXN3(Q89) by the ubiquitous CBh promoter can cause severe liver dysfunction and coagulation disorders, as reported in Cynomolgus Macaques [21,22], which may explain a cause of the early mortality of animals that received high doses of AAV-PHP.B encoding ATXN3(Q89).