For early-stage patients (stage I or II), surgical treatment can be combined with postoperative chemoradiotherapy; for stage III BC, patients mainly receive chemoradiotherapy, and a few receive mastectomy; for distant metastasis (stage IV) BC, patients only receive chemoradiotherapy, and hormone receptor (HR)-positive patients can choose endocrine therapy. The gene discussed is NR4A1; the disease is breast cancer.