For example, the NF-κB pathway can upregulate the expression of alpha-fetoprotein (AFP), which is regarded as a diagnostic and prognostic biomarker and a potential therapeutic target for HCC [60], and the NF-κB pathway has also been found to participate in the regulation of malignant phenotype of tumor cells [61]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.