Fused with Liposarcoma (FUS), one of the three members of FET family of proteins [FET is named after FUS, EWS (Ewing Sarcoma, and TAF15 (TATAbinding associated factor15)], has DNA and RNA binding affinity and is predominantly involved in transcription, splicing and alternative splicing [83,84]. The gene discussed is FUS; the disease is Ewing sarcoma.