Furthermore, elevated blood ammonia levels (Figure 2F,G) and decreased expression of genes encoding major urinary proteins (Mup1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, 21, FC > 1, p < 0.05, Figure S3) indicated a disruption of the urinary excretion mechanisms, reminiscent of the pathogenesis of hydronephrosis. Here, SLC25A19 is linked to hydronephrosis.