However, mice with a liver-to-kidney weight ratio <3.08 and high blood ammonia levels were common among mice with hydronephrosis (Figure 2H,I and Figure 4B) regardless of the genomic manipulations of the Tspan7 transgenic mice, suggesting that Otc may also be involved in hydronephrosis in wild-type and Cre driver mice. Here, OTC is linked to hydronephrosis.