OTC and hydronephrosis: That is, males were more susceptible to hydronephrosis-like conditions than females (Figure 3); the increased incidence of hydronephrosis-like pathology caused by Cre integration was not observed in fl/fl(6) female mice (Figure 3D and Table S2) but was observed in fl/y(X) mice (Figure 3B and Table S2), and ornithine transcarbamylase (Otc), one of the genes responsible for the urea cycle that converts ammonia to urea, is adjacent to Tspan7.