Notably, the patatin-like phospholipase domain-containing 3 (PNPLA3) gene variant (rs738409 c.444 C>G, p.I148M) on chromosome 22 has been linked to impaired triglyceride mobilization and increased hepatic lipid accumulation, thereby elevating the risk of HCC independently of other factors [82,83]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.