This signaling can also activate the inflammatory MAPK4 (MKK4)/c-Jun N-terminal kinase (JNK) pathway, stimulating the production of MMP2, MMP9, IL-6, IL-23, IL-17A, and TNFα, thereby fostering EMT and HCC invasiveness [114] (Table 3). This evidence concerns the gene IL6 and hepatocellular carcinoma.