Maternal inulin supplementation improved glucose metabolism impairment and insulin resistance by activating wnt family member 5a (Wnt 5a) methylation and inhibiting phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PiK3CA) methylation in offspring livers exposed to a maternal HFD (p < 0.01) [131]. The gene discussed is PIK3CA; the disease is Insulin resistance.