In renal cysts, we also identified the dysregulation of genes encoding multiple GSH-linked antioxidant enzymes, including superoxide dismutase (SOD1, −1.3×; SOD2, 1.8×), catalase (CAT, −1.6×), and glutathione S-transferase (GSTA1, −58×; GSTA3, −3.5×; GSTK1, −2,2×; GSTM5, 2.8×; GSTO1, 1.9×), glutathione peroxidase (GPX7 (1.9×), GPX8 (4.1×)), glutaredoxin (GLRX (−2.1×)), and peroxiredoxin (PRDX1, −1.2×; PRDX3, −1.7×; PRDX4, 2.8×; PRDX6, 1.4×). Here, GSTM5 is linked to cystic kidney disease.