To achieve this, we infected JNPL3 mice [46], an animal model of frontotemporal dementia (FTD) carrying the human P301L mutation in the Tau gene, and aged-matched C57 wild-type animals (WT) with adeno-associated viruses (AAVs) to express NCAP alone or in combination with SUMO2. This evidence concerns the gene SUMO2 and frontotemporal dementia.