The main findings of our study are that [1] NCAP expressed in the hippocampal neurons of WT as well as JNPL3 mice induced an increase in Tau phosphorylation, resulting in cognitive impairment, and that [2] an increase in the neuroprotective SUMO2 conjugation improved the behavioral outcomes in the models studied. The gene discussed is MAPT; the disease is Cognitive impairment.