SUMO2 and Cognitive impairment: We found that NCAP significantly reduced the performance of the WT animals compared with the WT animals injected with GFP, and we found that that SUMO2 overexpression rescued the cognitive impairment caused by NCAP in the WT mice (two-way ANOVA; AAV effect: p = 0.018, arm effect: p = 0.0006; Figure 5E).