MTOR and fibrosarcoma: AR stimulation activates the Src-rapidly accelerated fibrosarcoma (RAF)-MAPK kinase (MEK) pathway, resulting in MAPK activation [192,193,194,195], while ADT-resistance activates the phosphatidylinositol-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway, leading to mitogenic growth [196,197,198,199,200,201].