HMGB1 and metabolic dysfunction-associated steatotic liver disease: While HMGB1 serves as important mediator to accelerate local liver damage and systemic inflammation during the early stage of metabolic dysfunction-associated steatotic liver diseases (MASLD), it appears to coordinate tissue repair and inflammation by switching among alternative redox forms as fully reduced HMGB1 expedites repair processes by interacting with CXCR4 to induce immune cell recruitment [13].