Thus, in hypertension, in particular in the spontaneously hypertensive rat (SHR) model, a selective reduction of vasodilation induced by a variety of adenylate cyclase (AC) coupled agonists was observed in several arteries, which has been attributed to a reduced functional activity of the G-protein/AC pathway [2,3,4,5,6,7,8,9,10,11,12]. The gene discussed is ASAH1; the disease is hypertensive disorder.