CXCL8 and myocardial infarction: Signals released during tissue inflammation, such as growth factors (e.g., EGF) [26], cytokines (e.g., IL8/CXCL8) [27], and chemokines (e.g., CXCL10) [28], drive emergence in ex vivo models of dormancy; and chronic stressors such as major surgeries and myocardial infarction are related to subsequent emergence in humans [29,30].