Subsequently, NF-κB enters the nucleus to activate specific genes, transcribe NLRP3, activate NLRP3, and subsequently activate caspase-1 to shear the GSDMD, which creates a pore in the cell membrane, resulting in the efflux of inflammatory factors and the formation of pyroptosis, which promotes inflammation and results in DKD [67]. Here, CASP1 is linked to diabetic kidney disease.