This paper has reviewed the mechanisms of pyroptosis and its canonical, non-canonical, and caspase-3/8-mediated inflammatory pyroptosis pathways to the pyroptotic pathogenesis in DKD.The pathogenesis of DKD-related pyroptosis was proven associated with known signaling pathways activated by ROS, TLR4, lncRNAs, and P2X4/7 channels, and mediated by caspase-1, NLRP3, GSDMD, GSDME, caspase-4/5/11, caspase-3/8, and more exact mechanisms and upstream targets need to be well elucidated. Here, GSDME is linked to diabetic kidney disease.