In podocytes of glomeruli, DKD rats were shown with a dramatic increase in ATP-mediated intracellular calcium signaling, and the pharmacological use of the inhibitors of renal P2X4 and P2X7 facilitated the transition from metabotropic to ionotropic composition, alleviating intracellular calcium homeostasis [136]. Here, P2RX7 is linked to diabetic kidney disease.