P2X7R and NLRP3 inflammasome were involved in the pathogenesis of DKD, and Ophiocordyceps sinensis (ACOS) could effectively inhibit the high expression of P2X7R and the activation of NLRP3 inflammasome, which might contribute to the therapeutic effects of Ophiocordyceps sinensis in DKD [140]. Here, NLRP3 is linked to diabetic kidney disease.