In acute kidney injury, silencing lncRNA-Kcnq1ot1 released more miR-204–5p to inhibit NLRP3 expression and its inflammasome activation, while modulating the Kcnq1ot1/miR-486a-3p/NLRP3 and Kcnq1ot1/miR-506–3p/NLRP3 regulatory axis facilitated podocyte-targeted treatment for renal inflammatory diseases [123,124]. The gene discussed is NLRP3; the disease is acute kidney injury.