SYK and diabetic kidney disease: There were still other instances of upstream signaling of NLRP3 reported in pyroptosis of DKD and renal fibrogenesis, such as the spleen tyrosine kinase (Syk)/c-Jun N-terminal kinase (JNK)/NLRP3 pathway and receptor-interacting protein kinase-3 (RIPK3)/NLRP3 pathway [104,105].