CASP1 and diabetic kidney disease: In a recent study, Shahzad K. observed that specific deletion of Nlrp3 or caspase-1 in podocytes under hyperglycemic conditions could provide a protective effect against DKD by simultaneously enhancing Nlrp3 and caspase-1 function as well as weakening them in vivo, demonstrating activation of the NLRP3 inflammatory vesicle on podocyte adequacy and necessity in renal aseptic inflammation [53].