NLRP3 and diabetic kidney disease: It improved renal function and histopathological injury of DKD mice by alleviating podocytes injury, reducing ROS through the erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway, and weakening pyroptosis by inhibiting the NLRP3 inflammasome pathway [66].