NLRP3 and diabetic kidney disease: Swietenine (Swi), isolated from Swietenia macrophylla King, significantly improved the renal function of mice with DKD and inhibited the activation of NF-κB and the NLRP3 inflammasome and reduced inflammation by regulating the NF-κB/NLRP3/caspase-1 signaling pathway [96].