TLR4 and urogenital neoplasm: Synergistically, TLR4 (−/−) mice engrafted with wild-type hematopoietic cells had significantly lower serum creatinine and less tubular damage than wild-type mice reconstituted with TLR4 (−/−), suggesting that TLR4 signaling in intrinsic kidney cells played the dominant role in mediating kidney damage [72].