TXNIP and diabetic kidney disease: Tanshinone IIA (Tan IIA) is one of the main components of the root of red-rooted Salvia miltiorrhiza Bunge; it was reported recently regulating the oxidative stress and TXNIP/NIRP3 inflammasome inhibiting pyroptosis to delay the progression of DKD in db/db mice model and cultured human renal glomerular endothelial cells (HRGECs) [63].