Pyrroloquinoline quinone (PQQ), a naturally occurring bioactive, ameliorated renal fibrosis in DKD by inhibiting oxidative stress, phosphorylated NF-κB, the loss of mitochondrial transmembrane potential, and the NF-κB /NLRP3 pyroptosis pathway in DKD mice and high-glucose-treated HK-2 cells [95]. The gene discussed is NLRP3; the disease is renal fibrosis.