Astragaloside IV (AS-IV), an active constituent of Astragalus membranaceus, increased klotho levels in serum and renal tissues of DKD rats as well as in podocytes exposed to high glucose, reduced levels of oxidative stress and NF-κB activation, and attenuated NLRP3-mediated pyroprotein deposition in the glomeruli of DKD [93]. The gene discussed is NFKB1; the disease is diabetic kidney disease.