2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active component extract from Polygonum multiflorum Thunb, exhibits antioxidative and anti-inflammatory effects, and ameliorated DKD in rats with the involvement of SIRT1 and TGF-β1 pathways [100]. This evidence concerns the gene SIRT1 and diabetic kidney disease.