N6-methyladenosine (m6A) served as one of the most common mRNA modifications in eukaryotes, and its methylation was disturbed by lncRNA-LINC00342 through FTO, a demethylating enzyme of m6A in DKD, in addition to LINC00667 and LNC00963 affecting FTO expression, macrophage M1-regulated DKD is mediated by m6A methylation modification by lncRNA expression [109]. The gene discussed is FTO; the disease is diabetic kidney disease.