After intervention with Huangkui capsule (HKC), a modern Chinese effective medicine obtained from Abelmoschusmanihot, for 4 weeks, the expression levels of NLRP3, caspase-1, and IL-1β proteins were reduced in renal tissues of DKD animal models by suppressing TLR4/NF-κB signaling [82]. The gene discussed is TLR4; the disease is diabetic kidney disease.