LncRNAs metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression might enhance renal fibrosis in DKD rats and high-glucose-induced HK-2 cells via the miR-2355–3p/IL6ST axis, and further studies confirmed the MALAT1/miR-135b-5p/NLRP3 and MALAT1/miR-30c/NLPR3 signaling cascade in regulating LPS-induced inflammatory pyroptotic cell death and high-glucose-induced pyroptosis of renal tubular epithelial cells [120,121,122]. Here, NLRP3 is linked to renal fibrosis.