Treatment with 20(R)-ginsenoside Rg3, an active saponin isolated from ginseng (the root of Panax ginseng C. A. Meyer), in mice with DKD evaluated for 8 weeks down-regulated protein expression levels of MAPKs and NF-κB signal pathways in the kidney, improving insulin level, blood lipids, oxidative stress, and renal function [88]. The gene discussed is NFKB1; the disease is diabetic kidney disease.