For example, PRL stimulates keratinocyte proliferation [151], can promote angiogenesis [152], may enhance interferon gamma (IFN)-induced CXCL9, CXCL10, and CXCL11 production in keratinocytes, potentially promoting type 1 T cell infiltration into psoriatic lesions [153], and is associated with increases in Th1 and Th17 cytokine production in humans and in murine models of psoriasis [21,154]. This evidence concerns the gene PRL and psoriasis.