Not only was there a temporal relationship between the clinical signs of hyperprolactinaemia (irregular menses, gynaecomastia, and galactorrhoea) and the development of muco-cutaneous widespread blistering, but treatment with bromocriptine, the potent dopamine agonist which suppresses PRL secretion, resulted in rapid resolution of the skin changes. The gene discussed is PRL; the disease is Increased circulating prolactin concentration.