Not only was there a temporal relationship between the clinical signs of hyperprolactinaemia (irregular menses, gynaecomastia, and galactorrhoea) and the development of muco-cutaneous widespread blistering, but treatment with bromocriptine, the potent dopamine agonist which suppresses PRL secretion, resulted in rapid resolution of the skin changes. This evidence concerns the gene PRL and hyperprolactinemia.