Pemphigus vulgaris is an archetypical autoimmune disease characterised by the development of muco-cutaneous blister and erosions caused by the formation of autoantibodies targeting the dermosomal adhesion proteins desmoglein 3 and 1 may reportedly be triggered by stress in individuals with a genetic predisposition [92,93,94,95,96]. Here, DSG3 is linked to pemphigus vulgaris.