Several polymorphisms have been found in this gene, which is related to IBD, such as the TNF-α-238G/A [58], 308 G/A [58,59,60,61], -857 C/T [60,62], or 1031T/C [58,63], as well as TNF superfamily member 15 (TNF15) [64,65]. This evidence concerns the gene TNF and irritable bowel syndrome.