Examination of changes in the mitochondria of the skeletal muscle in the mouse cachexia model revealed no significant changes in mitochondrial volume (leucine zipper/EF-hand-containing transmembrane protein-1 [LetM1]), mitophagy markers (PTEN-induced putative kinase 1 [PINK1], Parkin), or OXPHOS markers (phosphocreatine) in the C and NT groups but decreased levels in the CX group (Table 5). Here, LETM1 is linked to Cachexia.