GPX4 and infection: Infections with RVs have been associated with several pathophysiological signatures of ferroptosis that drive respiratory tissue and organ damage, including the disruption of the cell redox homeostasis and depletion of glutathione peroxidase 4 (GPX4) and antioxidant glutathione (GSH) (Table 1) [72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90].