Specifically, the most prevalent neuropathological hallmarks are intracellular ubiquitin, TAR DNA-binding protein (TDP)-43-positive inclusions, microtubule-associated protein tau (MAPT), and fused in sarcoma (FUS) protein deposition, present in both hereditary and sporadic FTD [33,36]. This evidence concerns the gene TARDBP and frontotemporal dementia.