NOS2 and asthma: Figure 4 illustrates the inflammation process of the lungs in asthma; the results showed an overexpression of approximately twice to fourfold in the most important signaling proteins of the TLR4/NFκB/COX2/NOS2 pathway that concludes in the overexpression and production of proinflammatory cytokines and CD68, the membrane protein exclusive of macrophages.