Recognition of disease-associated molecular patterns DAMPS by immune-competent cells, such as tissue endothelial cells and macrophages, is favored during asthma exacerbation triggers the inflammatory response primarily by and adaptive immune reactions toll-like receptors (TLRs), especially lung endothelial TLR4 recognizes several exogenous ligands and activates a series of inflammatory cascades NFκB-dependent like macrophage activation and is involved in outward remodeling, promoting the inflammatory process [4,5]. The gene discussed is TLR4; the disease is asthma.