On the other hand, T2-high is the classical asthma presentation with large amounts of cytokines, such as IL-4 (produced by mast cells), IL-5 (produced by eosinophils), and IL-13, facilitating the synthesis of allergen-specific IgE and the accumulation of inflammatory cells, such as eosinophils, mast cells, basophils, and M2 macrophages. Here, IL4 is linked to asthma.