This study demonstrated the beneficial effect of the novel melatonin analogue Pir on IR by correcting systemic hyperglycemia and hyperinsulinemia in male and female offspring prenatally exposed to stress, as well as the ability of the drug to enhance the PNS-diminished GLUT4 expression in the hippocampus of male offspring. The gene discussed is SLC2A4; the disease is hyperinsulinism.