In the present study, we investigated the impact of combining 5-AZA and HDAC inhibition by SAHA against pancreatic cancer cell lines, and focused on the effect on mutp53 acetylation and stability as well as on other molecules interconnected with mutp53 and strongly involved in carcinogenesis such as c-myc and BRCA-1. This evidence concerns the gene BRCA1 and pancreatic neoplasm.