Thus, elevated macrophages–ECs and cholangioctes–ECs interactions via Nampt-Insr and Nampt-Itga5/Itgb1 were found in CHB mice livers, indicating the role of VISFATIN/Nampt- NF-κB axis in endothelial dysfunction and the Insr/Itga5-VEGF axis in angiogenesis. Here, ITGA5 is linked to endothelial dysfunction.