The activation of some JAK family members (JAK1, JAK2, and TYK2) is initiated by cytokines such as IFN-γ, IL-6, and those involved in the IL-23/IL-17 axis, which are known to drive the pathogenesis of psoriasis by promoting inflammation, immune cell activation, and abnormal keratinocyte growth. The gene discussed is IFNG; the disease is psoriasis.