ALS patients show chronic, low-grade systemic inflammation with elevated IL-6, IL-1β, and TNFα in the blood, which correlates with the degree of clinical disability, disease progression, and inflammatory markers, i.e., C-reactive protein (CRP), endotoxin-binding protein (LBP), and secreted CD14 (sCD14) molecules [195,196]. Here, LBP is linked to amyotrophic lateral sclerosis.