Ghanim et al. [30], studying a group of healthy subjects aged 20–50 years old, with a BMI < 25, receiving a high-carbohydrate high-fat diet, showed that diet-induced endotoxemia increased free radical levels, NFĸB activation, TLR2, and the expression of the suppressor of cytokine signaling-3 (SOCS-3), in contrast to subjects receiving a high-fiber diet with fruit. The gene discussed is SOCS3; the disease is serum lipopolysaccharide activity.