Interestingly, in a GMMG-BIRMA phase II study (NCT02834364), the combination of binimetinib and encorafenib in RRMM patients with a BRAF V600E or a BRAF V600K mutation showed an 82% overall response rate with 9 out of 11 MM patients having at least partial response [111,112]. The gene discussed is BRAF; the disease is Miyoshi myopathy.