APEX1 and Miyoshi myopathy: For example, Liao and colleagues reported that two major BER-related apurinic/apyrimidinic nucleases (APEX1 and APEX2) crosstalk with p73, a transcriptional regulator of RAD51, and results in its transcriptional upregulation, thus increasing the efficiency of homologous recombination (HR) and driving genomic instability in MM [32].