In future gene association studies of dental caries, other genes involved in Toll-like receptor-mediated pathogen recognition and/or regulation, such as TLR1 (Toll-like receptor 1 gene), TLR6 (Toll-like receptor 6 gene), and MD-2 (myeloid differentiation-2 gene), should also be considered [44]. Here, LY96 is linked to dental caries.