AGT and renovascular hypertension: Additionally, the synergic interaction between angiotensin II (Ang II) and rSNA contributes to the complexity of renovascular hypertension in 2K-1C rats, inducing various responses, including renal injury, increased oxidative stress and inflammation, reduced renal plasma flow (RPF), an increased glomerular filtration rate (GFR), and changes in sodium balance [7,8,9,10,11].