On the other hand, Willemse et al. evaluated Ng levels in the CSF of a dementia cohort consisting of AD patients, AD patients with high T-Tau, Creutzfeldt–Jakob disease (CJD) patients, and non-AD subjects and controls, concluding that Ng in the CSF represents a biomarker of synaptic degeneration, closely related to Tau but not specific to AD [50]. This evidence concerns the gene NRGN and Alzheimer disease.