ANXA5 and posterior cortical atrophy: Figure 4A depicts a representative experiment illustrating Annexin V/PI-stained PCa cells following treatment with DMSO, ARN, IACS and Combo. A significant increase in the apoptotic cells in LNCaP compared to control was observed upon treatment with ARN (4.5-fold, p = 0.0179), IACS (3.3-fold) and Combo (5.4-fold, p = 0.0043). The Combo treatment led to significant apoptosis induction in C4-2 cells, by 3.1-fold (p = 0.0063) compared to the control cells. No cytotoxicity was observed in PNT1A and PC-3 cells with our treatment regimen (Figure 4B).