The results demonstrated that expressions of LEP, PLXNA3, HLA-E, DDX58, IKBKE, VCAM1, HSPA6, SOS2, and HSPA1A were similarly upregulated in AD tissues (Figure S1B), and ROC curve analysis on this validation dataset further corroborated their high diagnostic values for AD (Figure S1C). Here, LEP is linked to Alzheimer disease.